A dataframe containing 10,000 iterations of a probabilistic analysis of a partitioned survival model. To access the original dataframe used in the scientific publication of PACBOARD (Pouwels et al. 2024), follow the link below.
Format
A dataframe with 10,000 rows, each row being the inputs and (intermediate) outputs of a single probabilistic iteration, and 46 variables:
- p_ae
Probability of occurence of an adverse event in the intervention stategy
- r_exp_pfs_comp
Rate of the exponential survival model used to estimate PFS of the comparator
- rr_thx_pfs
Relative risk of the occurrence of progression of the intervention versus the comparator, used to estimate PFS of the intervention
- r_exp_pfs_int
Rate of the exponential survival model used to estimate PFS of the intervention
- shape_weib_os
Shape of the Weibull survival model used to estimate OS of the comparator and intervention
- scale_weib_os_comp
Scale of the Weibull survival model used to estimate OS of the comparator
- rr_thx_os
Relative risk of the occurrence of death of the intervention versus the comparator, used to estimate PFS of the intervention
- scale_weib_os_int
Scale of the Weibull survival model used to estimate OS of the intervention
- u_pfs
Utility value (per cycle) associated with PFS health state
- u_pd
Utility value (per cycle) associated with PD health state
- u_d
Utility value (per cycle) associated with D health state
- u_ae
Utility decrement associated with the occurrence of an adverse event
- c_pfs
Costs (per cycle) associated with PFS health state
- c_pd
Costs (per cycle) associated with PD health state
- c_d
Costs (per cycle) associated with D health state
- c_thx
Costs (per cycle) associated with receiving treatment, in the PFS health state
- c_ae
Costs associated with experiencing an adverse event
- t_qaly_comp
Total undiscounted QALY obtained with the comparator, i.e. no treatment administered
- t_qaly_int
Total undiscounted QALY obtained with the intervention, i.e. treatment administered
- t_qaly_d_comp
Total discounted QALY obtained with the comparator, i.e. no treatment administered
- t_qaly_d_int
Total discounted QALY obtained with the intervention, i.e. treatment administered
- t_costs_comp
Total undiscounted costs obtained with the comparator, i.e. no treatment administered
- t_costs_int
Total undiscounted costs obtained with the intervention, i.e. treatment administered
- t_costs_d_comp
Total discounted costs obtained with the comparator, i.e. no treatment administered
- t_costs_d_int
Total discounted costs obtained with the intervention, i.e. treatment administered
- t_ly_comp
Total undiscounted LY obtained with the comparator, i.e. no treatment administered
- t_ly_int
Total undiscounted LY obtained with the intervention, i.e. treatment administered
- t_ly_d_comp
Total discounted LY obtained with the comparator, i.e. no treatment administered
- t_ly_d_int
Total discounted LY obtained with the intervention, i.e. treatment administered
- t_ly_pfs_d_comp
Total discounted life years accrued in PFS health state, comparator strategy
- t_ly_pfs_d_int
Total discounted life years accrued in PFS health state, intervention strategy
- t_ly_pd_d_comp
Total discounted life years accrued in PD health state, comparator strategy
- t_ly_pd_d_int
Total discounted life years accrued in PD health state, intervention strategy
- t_qaly_pfs_d_comp
Total discounted quality-adjusted life years accrued in PFS health state, comparator strategy
- t_qaly_pfs_d_int
Total discounted quality-adjusted life years accrued in PFS health state, intervention strategy
- t_qaly_pd_d_comp
Total discounted quality-adjusted life years accrued in PD health state, comparator strategy
- t_qaly_pd_d_int
Total discounted quality-adjusted life years accrued in PD health state, intervention strategy
- t_costs_pfs_d_comp
Total discounted costs accrued in PFS health state, comparator strategy
- t_costs_pfs_d_int
Total discounted costs accrued in PFS health state, intervention strategy
- t_costs_pd_d_comp
Total discounted costs accrued in PD health state, comparator strategy
- t_costs_pd_d_int
Total discounted costs accrued in PD health state, intervention strategy
- t_qaly_ae_int
Quality-adjusted life year decrement associated with the occurence of adverse events, intervention strategy
- t_costs_ae_int
Costs associated with the occurence of adverse events, intervention strategy
- inc_ly
Incremental QALYs obtained with the intervention versus the comparator
- inc_qaly
Incremental QALYs obtained with the intervention versus the comparator
- inc_costs
Incremental costs obtained with the intervention versus the comparator
Source
Pouwels XGLV, Kroeze K, van der Linden N, Kip MMA, Koffijberg H. Validating Health Economic Models With the Probabilistic Analysis Check dashBOARD. Value Health. 2024 Aug;27(8):1073-1084. doi: 10.1016/j.jval.2024.04.008.
Link to the original data ("df_pa_psm") used in the PACBOARD publication: https://github.com/Xa4P/pacheck/tree/master/data-raw